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This family protocol summary provides a general overview of the Children's Oncology Group (COG) study ANHL1131. It tells who is eligible and gives basic information about the study. More details about the study are in the consent form. You can get this from your oncologist.




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ANHL1131 is a Phase II/III clinical trial. A trial is another word for a study. The purpose of a Phase II trial is to learn if a new treatment works in treating a type of cancer and how it affects the body. In a Phase II trial, patients with a specific type of cancer receive a new treatment using a dose that was found to be safe in a Phase I trial. Patients are checked for side effects of the treatment and to see whether the cancer shrinks or goes away. Only a small number of patients with a relatively uncommon form of B cell lymphoma will be treated on the Phase II part of this trial.


The Phase III part of ANHL1131 compares two treatments. These treatments are called study arms. One study arm is the standard or the best proven current treatment. The other study arm has some changes or additions. The new treatment is thought to be at least as good as the standard treatment. It is not known if the new treatment will be better than the standard treatment.


Current treatment for children and adolescents with B-cell cancers results in cure for the majority of patients, but certain higher risk sub-groups of patients may not respond well to initial treatment or may have a return (relapse) of disease. The goal of ANHL1131 is to improve survival of children and adolescents with higher risk stages of B-cell lymphoma or B-cell leukemia (B-AL).


ANHL1131 will study Primary Mediastinal Large B-Cell Lymphoma (PMBCL) as the Phase II part of this study. PMBCL is an uncommon type of non-Hodgkin's lymphoma in children, and is more difficult to cure than other types of B cell lymphomas. Recent studies in adults have shown very promising results with the combination of rituximab with a chemotherapy regimen known as DA-EPOCH. DA-EPOCH includes the following chemotherapy drugs: Dose Adjusted - Etoposide, Prednisone, Vincristine (Oncovin), Cyclophosphamide, Doxorubicin ( Hydroxydaunorubicin). Using rituximab with DA-EPOCH has not been studied in children or adolescents.


In past studies of B-cell malignancies, the presence of cancer cells in the spinal fluid was a strong indicator of more aggressive disease. Therefore, in the ANHL1131 Phase III study, patients with lymphoma cells in the spinal fluid are considered the highest risk group, and will receive more chemotherapy. These children will be assigned to group C3 therapy. Children without any evidence of lymphoma in the central nervous system (CNS) will be treated in group B. Patients who have some evidence of disease in the brain or spinal cord, but do NOT have lymphoma cells in their spinal fluid will be treated in group C1.


Replacement for E85001 PC/SeaTalk/NMEA 0183 Interface Module - The Raymarine E85001 PC/SeaTalk/NMEA 0183 Interface Module was retired several years ago. Raymarine has not introduced a replacement for this device. The Shipmodul 1131, 1132, 1133, 1135, 1136 and 1137 have a bi-directional SeaTalk 1 interface which enables conversion between SeaTalk1 data and NMEA 0183 sentences. This conversation works both way, allowing the MiniPlex-3 units to replace Raymarine's discontinued SeaTalk - NMEA bridge E85001.


With Priority enabled, similar NMEA sentences on different inputs are only passed from the input with the highest priority. When for instance two GPS receivers are connected to inputs 1 and 2, and both transmit the same type of NMEA sentences, only those received on input 1 are passed. An adjustable time-out ensures that similar sentences from the GPS at input 2 are passed when the GPS at input 1 stops sending these sentences. Optionally, GPS sentences are checked for a valid status field, causing automatic switchover when the primary GPS looses satellite signal.


An unexpected error occurred:requests.exceptions.SSLError: HTTPSConnectionPool(host='acme-v02.api.letsencrypt.org', port=443): Max retries exceeded with url: /directory (Caused by SSLError(SSLEOFError(8, 'EOF occurred in violation of protocol (_ssl.c:1131)')))


A literature review of previous studies regarding CVD knowledge was conducted to identify potential items for the study instrument. Based on the literature search, the study questionnaire was adapted from validated surveys that were previously used in Australia, Pakistan, North Ireland, Canada, Jordan and South Africa [11, 12, 14, 15, 20, 21]. The content validity of the adapted questionnaire were established by a research group at Kuwait University. The questionnaire was translated into Arabic and subjected to a process of forward and backward translation. The accuracy and meaning of the translated versions both forward and backward were checked, and recommended amendments where necessary were discussed before being finalized. It was pretested for content, design, readability, and comprehension on 16 Kuwaiti subjects, and modifications were made as necessary so that the questionnaire was simple to understand and answer, yet gave accurate data.


All respondents who had diabetes and CHD reported taking medications for these diseases. Seventeen (23.3%) of the hypertensive patients, and 57 (51.4%) of those with dyslipidaemia admitted that they did not take medications for both diseases. Of the study population, 275 (33.7%), 367 (45%) and 343 (42%) reported that they did not know their recent measures for blood pressure, blood cholesterol and blood glucose, respectively. About one-fifth (19.7%) of respondents had never checked their blood pressure, and approximately one-quarter had never checked their blood cholesterol (27.2%) and glucose (24.4%) levels.


I have consoled into an 1131AG LWAPP but i can get past the user exec mode > . I have checked the doc on the default password "Cisco" which is case sensitive and commands are not available in this mode to erase private-config file.I have reset the controller to factory but still i am prompted with the password which by default should be cisco.Please assist.


CIsco AIR LAP1131AG E K9 Status LED = Yellow; Ethernet LED = Off; Radio LED = blinking Red in a pattern, red off then red red, Our AP isn't working it won't show up on our Cisco WLC 2125 anymore and this is the LED indicators, I've checked in the manual and this combination of LEDs do not exists??


@margaret2022: No, I haven't checked out FB. Actually I don't have a FB page so I guess any forum on there would have to public vs. private in order for me to access it (if that's how FB works - Lol).


Once your periodontal treatment has been completed, your dentist and dental hygienist will recommend that you have regular maintenance cleanings (periodontal cleanings), usually four times a year. At these cleaning appointments, the pocket depths will be carefully checked to ensure that they are healthy. Plaque and calculus that is difficult for you to remove on a daily basis will be removed from above and below the gum line.


On my RD Server I keep getting the error "no licensing servers available". I've checked my RD set up and EVERYTHING looks right. When I go to event viewer, custom views, server roles, I get a TermialServices-RemoteConnectionManager warning event 1131. The Remote Desktop Host server could not contact the RD License server xx.xxx.x.xxx (Old license server ip). Ensure that the RD Licensing service is running on the license server, that the license server is accepting network requests, and that the license server is registered in wins and DNS. How do I fix this?


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